The Mumbai Cohort Study (MCS) was the first large study to employ house-to-house recruitment as well as follow-up using hand-held computers. The study not only demonstrated successful methods to conduct large cohort studies in low-resource countries but ensured very high response rate (~95% after an average 5.5 years of follow-up). The study was conducted with the aim to study the diversity and socio-demographic characteristics of tobacco use in Mumbai, India. The study reported for the first time about the excess all-cause and cause-specific mortality from various forms of tobacco use other than cigarette smoking. The study concluded for the first time that bidi smoking is no less hazardous than cigarette smoking, and smokeless tobacco use may also result in significantly increased mortality.
The cross-sectional data were also used to study association of different exposures with the self reported health outcomes such as TB and diabetes. Using MCS cross-sectional data we have successfully demonstrated the feasibility of linking Population Based Cancer Registry (PBCR) data with MCS data and studied the association of tobacco habits with overall and site specific cancer incidence in Mumbai.
Prospective Cohort Study
Started1999 - second follow up ended - 2018
Dr. Prakash C. Gupta / Dr. Mangesh Pednekar
1,50,000 individuals aged > or =35 years were recruited in Mumbai, India in years 1991-1997 and have been followed up since then.
This study was done to perform a case-control analysis to test the hypothesis that candidate SNPs are associated with increased BcCA risk and that subjects with both poor (pro-inflammatory, high-fat) diets and candidate risk genotypes have even greater BrCA risks compared to subjects without a risk allele and with more healthy diets.
Genetic and Dietary Case-Control study of Breast Cancer
Arnold School of public Health, Tata Memorial Hospital and Healis – Sekhsaria Institute for Public Health.
Dr. Jim Burch, James Herbert (Co-investigator), Susan E. Steck (Co-investigator), Dr. Rajiv Sarin (Co-investigator), Dr. P.C. Gupta (Co-investigator)
Altogether, we had 2357 diet forms (FFQs) received, coded and shared from ACTREC so far with the team. Details of the Food frequency questionnaires are as follows:
BGSC (Sporadic Cases) -1183
BGFC (Familial Cases) -064
BGSN (Sporadic Normal) -1086
BGFN (Familial Normal) -024
This is a consortium of Cohorts in Asia conducting joint analysis that includes over million individuals. Mumbai Cohort study data are contributed to this Consortium.
Meta-analysis of Cohort Studies